In 2006, Hasbro released X-Men: The Last Stand action figures of Jean Grey, Beast, Juggernaut and Colossus. Unlike the past X-Men films, which had received their own dedicated toylines, Hasbro opted to release the Last Stand figures in the super-posable Marvel Legends line, with Beast appearing in the Annihilus Build-a-Figure wave, Jean Grey and Juggernaut appearing in the Blog wave, and Colossus appearing in the Brood Queen wave.

Wolverine and Cyclops were not included in the initial Legends wave, but were later released in a pair of two-packs alongside rereleased figures of Beast and Colossus, respectively, to celebrate the release of X-Men Origins: Wolverine.

Hot Toys also released an action figure for the movie.