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Trivia about Fantastic Four.
- Saoirse Ronan, Allison Williams and Margot Robbie auditioned for the role of Susan Storm. Mara was eventually cast.
- Kit Harington, Anton Yelchin and Jack O'Connell auditioned for the role of Reed Richards. Teller was cast after auditioning.
- Eddie Redmayne, Jack Huston, Toby Kebbell, Domhnall Gleeson and Sam Riley were considered to play Dr. Doom. Kebbell was the studio's first pick and eventually cast.
- Christian Cooke auditioned for the role of The Thing before Bell was cast.
- Michael B. Jordan ran into Chris Evans, who initially played Johnny Storm in Fantastic Four (2005) and its sequel, at an industry event. According to Jordan, they ended up talking about the role and according to Jordan, Evans said "'Man I can't give you anything.' He said, 'You're great, you're awesome. Just do your thing. And enjoy it. It's gonna be fun.'"
- Michael B. Jordan was Josh Trank's first choice to play Johnny Storm.
- Miles Teller and Michael B. Jordan both previously appeared on the comedy That Awkward Moment.
- The filmmakers cite the "Ultimate Fantastic Four" comics, Sam Raimi's Spider-Man trilogy and Josh Trank's Chronicle (2012) as an influence on the film.
- Released a decade after 2005's "Fantastic Four", which the film is a reboot of.
- Writer Simon Kinberg described the story as "a celebration of all the Fantastic Four comics, the notion of this dysfunctional surrogate family of scientists that come together and this idea that it's almost more like a science adventure than a superhero film."
- This is not Tim Blake Nelson's first time appearing in a movie based on Marvel comic characters. He previously had a supporting role in the 2008 Marvel film The Incredible Hulk with Edward Norton.
- The uniforms the Fantastic Four wear are based on containment suits.
- The origin of the Fantastic Four (a lab experiment involving a portal to another dimension goes wrong, and the Four get mutated by radiation from the experiment) is based on their "Ultimate Marvel" origin.
- When Susan is tracking a signal, there is an IP address on a screen: "22.214.171.124". This will lead to online articles for Latveria, Dr Doom's homeland.
- The filmmakers cite Sam Raimi's Spider-Man trilogy, David Cronenberg's sci-films The Fly (1986) and Scanners (1981) and Josh Trank's Chronicle (2012) as an influence on the film.
- The music in the trailer is also the theme tune to Broadchurch.
- Josh Trank made the Storm family of mixed race to represent his view of 21st century families: "I have mixed family. When I go home for Christmas, you'll see white people and black people; that's normal to me."
- According to Toby Kebbell, the hardest part about playing Dr Doom was getting his voice right.
- Kate Mara had previously appeared in an episode of Robot Chicken as the Invisible Woman.
- This is the second Marvel film for both Tim Blake Nelson and Kate Mara, who had both appeared in Marvel sequels: Nelson had appeared in The Incredible Hulk and Mara had appeared in Iron Man 2.
- Kiefer Sutherland was the original choice for Ben Grimm.
- For the first time, the Thing will be created in computer-generated imagery rather than through prosthetics and make-up.
- The film is using OTOY for the VFX, which according to Josh Trank, was specifically chosen for working at low costs.
- The fourth Fantastic Four film.
- Sasha Pieterse auditioned for the role of Susan Storm, but was considered too young for the part. Kate Mara was later cast.
- Samira Wiley was at one point considered for the role of Susan Storm/The Invisible Woman.
- The film's portrayal of Harvey Elder (Mole Man) is based on the Marvel "Ultimate" character (a scientist and contemporary of Dr Franklin Storm).
- The white uniforms the team wears on their trip to the Negative Zone are based on the Fantastic Four's "Future Foundation" uniforms.
- Will be Kate Mara's second time playing a member of a team of superheroes, the first being in Zoom (2006).
- In Tim Story's "Fantastic Four" series, Alicia Masters was black. In this film, it is Johnny Storm and his father (but not Susan Storm, who is an adopted child).
- The origin of the Fantastic Four and Doctor Doom (a lab experiment involving a portal to another dimension goes wrong, and all five get mutated by radiation from the experiment) is based on their "Ultimate Marvel" origin.
- Michael B. Jordan described the story as: "a bunch of kids that had an accident and have disabilities now that they have to cope with, and try to find a life afterwards."